Keto - Gynelogic

Periodical articles|Primary Research

Keto|Metabolic energy switch|Microbiome|Osteoporosis

Endocrinal metabolic regulation on the skeletal system in post-menopausal women

Loss of estrogen results in reduced osteoblast mediated bone formation and enhanced osteoclastic resorption (Emmanuelle et al., 2021). Given the recent expansion of interest in understanding how these cellular processes are regulated via metabolic flux and…
Primary Research

Dementia|Keto|Metabolic energy switch

Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

Brain hypometabolism precedes clinical signs ofAlzheimer’s disease: Frackowiak et al. (1981) found a decline in cerebral bloodﬂow and mean cerebral oxygen utilization, i.e., hypometabolism, which is correlated with the severity of dementia. Global oxygen…
Primary Research

Brain|Dementia|Insulin Signalling|Keto|Metabolic energy switch|Mitochondria|Myelin

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer’s Disease

White matter degeneration is a pathological hallmark of neurodegenerative diseases including Alzheimer’s. Age remains the greatest risk factor for Alzheimer’s and the prevalence of age-related late onset Alzheimer’s is greatest in females. We investigated…
Primary Research

Brain|Dementia|Depression|Hot flushes|Insulin Signalling|Keto|Metabolic energy switch|Mitochondria

Perimenopause as a neurological transition state

Estrogen-mediated regulation of the bioenergetic system: estrogen signalling supports and sustains glucose metabolism in the brain by regulating expression of glucose transporters, which results in increased glucose uptake, and by stimulating glucose metabolism, mitochondrial…
News, views and reviews

Brain|Insulin Signalling|Keto|Metabolic energy switch|Mitochondria

Lupron, Brain Function, and the Keto Diet

In the absence of estradiol, brain glucose transport diminishes significantly. This effectively starves the brain for energy inducing severe bioenergetic deficiencies with all of the concordant neuronal damage one might expect. The reduction in…
Primary Research

Brain|Insulin Signalling|Keto|Metabolic energy switch|Mitochondria|Muscle

Low Estrogen Exposure and/or Defective Estrogen Signaling Induces Disturbances in Glucose Uptake and Energy Expenditure

Estradiol and its receptors are key players in the physiology and insulin production capacity of the β cells of pancreatic islets. Estradiol administration is associated with pancreatic islet hypertrophy and increased insulin release from…
Primary Research

Brain|Insulin Signalling|Keto|Metabolic energy switch|Mitochondria

Estrogen: A master regulator of bioenergetic systems in the brain and body

Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen…
Primary Research

Keto|Low carb|Migraines/headaches

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

This article presents a hypothesis explaining the cause of migraines, suggesting that electrolyte imbalance, specifically a lack of sufficient sodium in the extracellular space of sensory neurons, leads to failed action potentials. The author…
Primary Research

Brain|Dementia|Keto|Metabolic energy switch|Mitochondria

Mitochondria, Estrogen and Female Brain Aging

During perimenopause, the drop in oestrogen leads to reduced glucose metabolism and increased ketogenic (fat burning) metabolism in the brain.
News, views and reviews

Insulin Signalling|Keto|lupron|Metabolic energy switch|Mitochondria|Oophorectomy

Tank Estradiol and Lose Metabolic Flexibility: Pitfalls of Lupron and Oophorectomy

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What’s New in Keto

Endocrinal metabolic regulation on the skeletal system in post-menopausal women

Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer’s Disease

Perimenopause as a neurological transition state

Lupron, Brain Function, and the Keto Diet

Low Estrogen Exposure and/or Defective Estrogen Signaling Induces Disturbances in Glucose Uptake and Energy Expenditure

Estrogen: A master regulator of bioenergetic systems in the brain and body

Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective

Mitochondria, Estrogen and Female Brain Aging

Tank Estradiol and Lose Metabolic Flexibility: Pitfalls of Lupron and Oophorectomy

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