Journal

What’s New in Brain


  • In post-menopausal women, the earliest change in the brain appears to be a fall in the amount of glucose used by the brain, indicating reduced brain activity. This is due to falling estrogen levels,…


  • Hot flashes during sleep may be an early marker of a woman’s risk for developing Alzheimer disease (AD), according to the results of a study presented at the 2023 Annual Meeting of the Menopause…


  • A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment represents a transition between normal cognition and dementia. The frequency of cognitive changes is higher in women than in men. Based on this…


  • White matter degeneration is a pathological hallmark of neurodegenerative diseases including Alzheimer’s. Age remains the greatest risk factor for Alzheimer’s and the prevalence of age-related late onset Alzheimer’s is greatest in females. We investigated…


  • Estrogen-mediated regulation of the bioenergetic system: estrogen signalling supports and sustains glucose metabolism in the brain by regulating expression of glucose transporters, which results in increased glucose uptake, and by stimulating glucose metabolism, mitochondrial…


  • In the absence of estradiol, brain glucose transport diminishes significantly. This effectively starves the brain for energy inducing severe bioenergetic deficiencies with all of the concordant neuronal damage one might expect. The reduction in…


  • Estradiol and its receptors are key players in the physiology and insulin production capacity of the β cells of pancreatic islets. Estradiol administration is associated with pancreatic islet hypertrophy and increased insulin release from…


  • Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen…


  • During perimenopause, the drop in oestrogen leads to reduced glucose metabolism and increased ketogenic (fat burning) metabolism in the brain.


  • Coming across Louann Brizendine’s book about menopause was a moment of sheer joy. The Upgrade – which is exactly how I see menopause – links the physical metabolic changes that declining oestrogen brings, to…

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FEATURED IN:
Sandra Ishkanes
Functional Medicine Practitioner
BSc MA DipION

sandra@gynelogic.co.uk
Brighton, UK

You can restore your health, all you need is the knowhow.

My mission is to provide trusted guidance and information to make menopausal health and wellbeing more accessible and attainable to all women.

My goal is to help women feel confident in their bodies and their future and to do so I create healthcare that empowers women by providing the tools and education to restore functionality so that their bodies are whole again.

My method is simple: I remove what is harmful and add what is beneficial based on cutting-edge science and traditional wisdom. In this way l provide effective and natural healthcare solutions for women of all ages.
Partner with me to feel healthier, look great, and increase your energy and resiliency to better deal with life’s stresses.