Primary research

Association of Menopausal Vasomotor Symptoms With Increased Bone Turnover During the Menopausal Transition

The purpose of this study was to determine the longitudinal association between menopausal vasomotor symptoms (VMS) and urinary N-telopeptide level (NTX) according to menopausal stage.

We conclude that among early perimenopausal and late perimenopausal women, those with VMS had higher bone turnover than those without VMS. Prior to the final menstrual period, VMS may be a marker for risk of adverse bone health. 

…high bone turnover is associated with lower bone mineral density, faster bone loss, and poor bone microarchitecture both in the trabecular compartment (trabecular perforations, loss of trabeculae, poor trabecular connectivity) and in the cortical compartment (cortical thinning, increased porosity).